The suggestions you receive will be based on the data you provide from your system.
(After analysis of your GLOBAL STATUS and GLOBAL VARIABLES data from one system. Your specific server's analysis results will likely be ONLY similar).
Suggestions for your my.cnf-ini [mysqld] section
time saving tip for you, place at the END of [mysqld] section to replace old requests.
Last one processed, will be used for the instance.
Leave old values and you will have a history of all changes,
in chronological order.
To avoid confusion, you may wish to retain only the LAST used variable to avoid multiple lines with the same named variable in your my.cfg-ini.
Your my.cnf likely includes 4 lines that should be removed preferably (or disabled with leading #), they are sort_buffer_size read_buffer_size read_rnd_buffer_size join_buffer_size these are all per connection RAM requirements and may be driving your RAM footprint much higher than necessary.
Let the DEFAULTS work for you to improve response time with room to breathe in RAM.
Consider adjusting the following in your my.cnf-ini, please
key_buffer_size=512M # from 1G because 200M is used now
innodb_buffer_pool_size=4G # to match RAM reported by MySQLTuner
max_connections=100 # from 500, until more than 8 are used
thread_cache_size=100 # from 192 MySQL see v 8 refman
that recommends CAP of 100 to avoid OOM crash
query_cache_limit remove to allow default of 1M rather than 32M
query_cache_min_res_unit=512 # from 4K to store more RESULTS
table_open_cache=10000 # from 2000 to support ~ 28,000 tbls opened
No more than one SUGGESTION per day to be applied, monitor.
Many of these variables may be DYNAMICALLY modified (with SET GLOBAL variable_name=xxxx;) and will be in effect with the NEXT User Login for the sessions they run.
Updating your active my.cnf-ini will be applicable after services shutdown/restart of your instance for this server.
Refer to your user manual for details.
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